Shaomeng wang group umichigan
Webb23 dec. 2014 · [email protected] Office: 734-615-0362 Lab: 734-615-3699 Web Sites ↓ Areas of Interest Structure-based design and synthesis of molecular target-specific … WebbIncluding their publications and grants. Skip to main content. All experts. ABOUTSCHOLARLY ACTIVITIESGRANTS. Shaomeng Wang has not uploaded a photo. …
Shaomeng wang group umichigan
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Webb11 nov. 2024 · Based on our previous STAT3 SH2 domain inhibitor CJ-887 (compound 1) (Chen et al., 2010a), we have performed extensive optimization, as summarized in Figure 1 A, to obtain potent and cell-permeable STAT3 inhibitors.First, we designed compound 2 by cyclization of the amino group with the phenyl group to form an indole, which binds to …
WebbThe natural product-like compound 1 was identified as a direct inhibitor of the menin–MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2. WebbShaomeng Wang. University of Michigan. Verified email at umich.edu ... Computer automated log P calculations based on an extended group contribution approach. G …
Webb7 sep. 2024 · A highly efficient strategy for remote reductive cross-electrophile coupling has been developed through the ligand-controlled nickel migration/arylation. This general protocol allows the use of abundant and bench-stable alkyl bromides and aryl bromides for the synthesis of a wide range of structurally diverse 1,1-diarylalkanes in excellent yields … WebbAntitumor activity of APG-2449 was evaluated in mice bearing subcutaneous tumors derived from H3122 NSCLC cells carrying EML4-ALK fusion gene (A; treated for 3 weeks, n = 7 per treatment group; T/C values were assessed on Day 21), KARPAS-299 cells carrying NPM-ALK fusion gene (B; treated for 3 weeks, n = 7 per treatment group; T/C values were …
WebbAfter spending one year as a Postdoctoral Research Fellow at Purdue University, USA, he joined the Wang Lab in 2016. Currently focused on the development of novel small molecule inhibitors (EED/LSD1) and drug-like properties for optimization of PROTACs. Lingying Yeng Research Fellow [email protected] Ph.D. Sichuan University, China …
WebbWang LD, Shaomeng Wang and Sun D. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of an Antagonist (SM406/AT-406) of Multiple Inhibitor of … dynamite and cesium-137WebbAdministrative Assistant, Senior . [email protected]. Nicholas VanDyke. Lab Manager. [email protected] dynamite alternativeWebbAfter spending one year as a Postdoctoral Research Fellow at Purdue University, USA, he joined the Wang Lab in 2016. Currently focused on the development of novel small … dynamite and garageWebb27 okt. 2024 · The bicyclic aromatic group of DI-591 is buried in a deep hydrophobic pocket defined by I86, F89, C90, F109, ... Haibin Zhou, Jianfeng Lu, Liu Liu, Denzil Bernard, Chao-Yie Yang & Shaomeng Wang. dynamite agencyWebbTo accomplish our goals of discovering highly optimized compounds suitable for clinical development and rapidly advancing them into clinical development, Dr. Wang ha s established extensive collaborations with basic scientists, translational scientists and clinical investigators at UMCCC and in other institutions. cs2 boiling ptWebbResponsibilities will include: design and synthesis of small-molecule degraders and inhibitors in close collaborations with other members of the laboratory. Salary $50,000 - … dynamite and davey bookWebb1 nov. 2024 · Shaomeng Wang, Ph.D. Warner-Lambert/Parke-Davis Professor in Medicine. Professor of Medicine, Pharmacology and Medicinal Chemistry. Director, Cancer Drug … cs2 beta torrent