High affinity copper uptake protein 1-like

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WebCopper is imported into eukaryotic cells through high-affinity copper transporters of the family of Ctr permeases. 9 To date, Ctr transporters are the best-characterized system … Web1 de abr. de 2024 · Inducible high-affinity copper uptake is key to copper homeostasis in Chlamydomonas reinhardtii. We generated cDNAs and updated gene models for four genes, CTR1, CTR2, CTR3, and COPT1, encoding ...

LOC106138791 high affinity copper uptake protein 1-like []

Websible that the fusion of S. cerevisiae Ctr1 and Ctr3-like proteins may be an early event that led to the evolution of high affinity copper transport proteins of other eukaryotes (15, 17). Since most eukaryotic high affinity copper transporters iden-tified to date have strong homology to Ctr3, it is important to Web24 de jun. de 2003 · The hCtr1 protein functions in high affinity copper uptake. Copper is delivered by an unknown mechanism to three different metallochaperones, hCCS, ATOX1 and hCOX17. The delivery of copper to SOD1 is mediated by hCCS. The pathway involving copper delivery to cytochrome oxidase in the mitochondria requires the hCOX17 copper … the point wine and spirits whitney point ny

Deregulated copper transport affects Arabidopsis development …

WebCopper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily … WebIt has been claimed that human copper transporter 1 (hCTR1), the human high-affinity copper transporter, is the major entry pathway for cDDP and related drugs via a mechanism that mimics copper. This is an unexpected property of … Web30 de mar. de 2024 · Functional assays revealed that it stimulates the initial rate of radiolabeled copper uptake. CTR1 transports copper with high affinity in a time-dependent and saturable manner and is copper-specific. Transport is an energy-independent process and is stimulated by extracellular acidic pH and high K+ … the point winery

SLC31A1 - High affinity copper uptake protein 1 - Function

Web11 de mai. de 2024 · At physiological pH, NGF peptides bind one equivalent of copper ion with higher affinity of Aβ and lower than hCtr1 peptide fragments. Therefore, in the synaptic cleft, NGF may act as a potential copper chelating molecule, ionophore or chaperone for hCtr1 for metal uptake. Web11 de abr. de 2024 · Several lines of evidence presented here strongly suggest that the first histidine (His43) upstream from TMD1 is absolutely required for the copper transport activity of COPT1 protein. Firstly, deletion of 43 residues, but not 41 residues, of the extracellular N-terminus, completely blocked high affinity copper uptake of COPT1. sidharth malhotra godfatherWeb1 de jan. de 2024 · This high-affinity copper transporter takes up Cu + from the intestinal lumen to the epithelial cell, in an energy-independent manner [2], [3]. CTR1 is the major copper importer present on the apical site of enterocytes, but conflicting reports have also shown a possible role of DMT1 in copper transfer into intestinal cells. the point with mindy todd

"WebHigh affinity copper uptake protein 1: Synonyms: Copper transporter 1; Solute carrier family 31 member 1; hCTR1; Gene Name: SLC31A1: Protein Type: Transporter: Biological Properties; ... structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. " - High affinity copper uptake protein 1-like

High affinity copper uptake protein 1-like

Normal Human Copper Metabolism - ScienceDirect

Web27 de mar. de 2024 · Copper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. … WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function

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WebHigh affinity copper uptake protein 1 is a protein that in humans is encoded by the SLC31A1 gene.[5][6] For faster navigation, this Iframe is preloading the Wikiwand page … Webencode a high affinity copper uptake process and was found to be 29% identical at the primary structure level with Ctr1 from yeast. The human protein was, however, substantially smaller than the yeast protein, being composed of 190 amino acids as compared with 406 amino acids (see Fig. 1). hCTR1 is on the

WebChemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells. The signals of chemokines/chemokine receptors guide various leukocytes to respond to inflammatory reactions and infectious agents. Many chemokine receptors play supportive … High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais

Web28 de nov. de 2024 · DOI: 10.3389/fmolb.2024.1055356 Abstract More than a decade ago, studies on cellular cisplatin accumulation via active membrane transport established the role of the high affinity copper uptake protein 1 (CTR1) as a main uptake route besides passive diffusion. WebHigh affinity copper uptake protein 1: Synonyms: Copper transporter 1; Solute carrier family 31 member 1; hCTR1; Gene Name: SLC31A1: Protein Type: Transporter: …

WebThese high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The …

WebGene ID: 100178573, updated on 26-Oct-2024. Summary Other designations. high affinity copper uptake protein 1-like the point x y lies on the line 2x+3y 6Web13 de abr. de 2024 · Expression and affinity purification of recombinant proteins. Recombinant proteins were purified by Ni-NTA affinity column (detected by western blot). The gel was stained with Coomassie brilliant blue G250 (CBB G250). (A) Western blot analyses of the recombinant Rh14-3-3ζ and Rh14-3-3ε protein. sidharth malhotra debut movieWeb5 de abr. de 2024 · Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion Epub 2024 Feb 22. Authors Gulshan Walke 1 … the point x y y x only ifWeb25 de set. de 2024 · Abstract Copper is crucial for carrying out normal physiological functions in all higher life forms. Copper Transporter 1 (CTR1) is the high-affinity copper importer found in all eukaryotic organisms. The copper transporter family primarily comprises ~ six members (CTR1-6) and the related members share high sequence … the point work experienceWeb21 de abr. de 2011 · COPT7 alone could mediate a high-affinity Cu uptake in the yeast mutant. None of the seven COPTs alone or in cooperation could complement the phenotypes of S. cerevisiae mutants that lacked the transporter genes either for iron uptake or for zinc uptake. the point within the circleWebHigh affinity copper uptake protein 1 Kind protein Organism Humans Protein. Name UniProt ID; High affinity copper uptake protein 1: O15431: Details: Drug Relations … the point winthrop harborWebTransport of ferrous iron (Fe 2+). Fe 2+ uptake is carried out by proteins involved in high-affinity uptake systems and general divalent metal ion transporters. The two most widely distributed eukaryotic divalent metal-ion uptake protein families are Natural Resistance Associated Protein (NRAMP) and Zinc-Regulated Transporter (ZRT)-Iron-Regulated … sidharth malhotra marriage date